Serum Sclerostin and Bone Turnover in Latent Autoimmune Diabetes in Adults
Author(s) -
Nicola Napoli,
Rocky Strollo,
Giuseppe Defeudis,
Gaetano Leto,
Chiara Moretti,
Simona Zampetti,
Luca D’Onofrio,
Giuseppe Campagna,
Andrea Palermo,
Valentina Greto,
Silvia Manfrini,
Mohammed I. Hawa,
Richard David Leslie,
Paolo Pozzilli,
Raffaella Buzzetti
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2017-02274
Subject(s) - sclerostin , medicine , endocrinology , type 2 diabetes , n terminal telopeptide , diabetes mellitus , bone remodeling , body mass index , osteocalcin , chemistry , biochemistry , wnt signaling pathway , alkaline phosphatase , enzyme , gene
Bone formation is impaired in both type 1 diabetes and type 2 diabetes (T2D), whereas sclerostin, an antagonist of bone formation, is increased in T2D only. No data are available on latent autoimmune diabetes in adults (LADA), an autoimmune type of diabetes that may clinically resemble T2D at diagnosis. We evaluated serum sclerostin and bone turnover markers in LADA compared with those in T2D and whether metabolic syndrome (MetS) affects sclerostin in T2D or LADA.
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