Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts | Zendy

Laura A. Marlow | Zendy; Stephen D. Rohl | Zendy; James L. Miller | Zendy; Jeffrey A. Knauf | Zendy; James A. Fagin | Zendy; Mabel Ryder | Zendy; Dragana Milosevic | Zendy; Brian C. Netzel | Zendy; Stefan K. Grebe | Zendy; Honey V. Reddi | Zendy; Robert C. Smallridge | Zendy; John A. Copland | Zendy

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Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts

Author(s) -

Laura A. Marlow,

Stephen D. Rohl,

James L. Miller,

Jeffrey A. Knauf,

James A. Fagin,

Mabel Ryder,

Dragana Milosevic,

Brian C. Netzel,

Stefan K. Grebe,

Honey V. Reddi,

Robert C. Smallridge,

John A. Copland

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2017-01845

Subject(s) - thyroid cancer , thyroid , pax8 , medicine , cancer , cancer research , cell culture , pten , oncology , pathology , biology , pi3k/akt/mtor pathway , genetics , transcription factor , gene , apoptosis

To investigate the molecular underpinnings of thyroid cancer, preclinical cell line models are crucial; however, ∼40% of these have been proven to be either duplicates of existing thyroid lines or even nonthyroid-derived lines or are not derived from humans at all. Therefore, we set out to establish procedures and guidelines that should proactively avoid these problems, which facilitated the creation of criteria to make valid preclinical models for thyroid cancer research.

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