The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma
Author(s) -
Huiling He,
Wei Li,
Sandya Liyanarachchi,
Yanqiang Wang,
Lianbo Yu,
Luke K. Genutis,
Sophia E. Maharry,
John E. Phay,
Rulong Shen,
Pamela Brock,
Albert de la Chapelle
Publication year - 2017
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2017-01798
Subject(s) - biology , gene knockdown , microbiology and biotechnology , single nucleotide polymorphism , thyroid carcinoma , chromatin immunoprecipitation , candidate gene , gene , gene isoform , genetics , gene expression , cancer research , thyroid , genotype , promoter
Previous genome-wide association studies have shown that single-nucleotide polymorphism (SNP) rs2439302 in chromosome 8p12 is significantly associated with papillary thyroid carcinoma (PTC) risk and dysregulated NRG1 expression. The underlying mechanisms remain to be discovered.
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