Amino Acid and Fatty Acid Levels Affect Hepatic Phosphorus Metabolite Content in Metabolically Healthy Humans
Author(s) -
S. Kahl,
Bettiowotny,
Klaus Straßburger,
Alessandra Bierwagen,
Birgit Klüppelholz,
Barbara Hoffmann,
Guido Giani,
P. Nowotny,
Franziska Wallscheid,
Erifili Hatziagelaki,
Giovanni Pacini,
Jonghee Hwang,
Michael Roden
Publication year - 2017
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2017-01773
Subject(s) - metabolite , phosphorus , fatty acid , biochemistry , affect (linguistics) , chemistry , amino acid , food science , biology , psychology , organic chemistry , communication
Hepatic energy metabolism negatively relates to insulin resistance and liver fat content in patients with type 2 diabetes, but its role in metabolically healthy humans is unclear. We hypothesized that intrahepatocellular γ-adenosine triphosphate (γATP) and inorganic phosphate (Pi) concentrations exhibit similar associations with insulin sensitivity in nondiabetic, nonobese volunteers.
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