Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Author(s) -
Clare A. Flannery,
Gina Choe,
Katherine Cooke,
Andrew G. Fleming,
Caitlin C. Radford,
Pinar H. Kodaman,
Michael J. Jurczak,
Richard G. Kibbey,
Hugh S. Taylor
Publication year - 2018
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2017-01759
Subject(s) - endocrinology , medicine , insulin , glycogen , glycogen synthase , glycogenesis , biology , hyperinsulinemia , endometrium , carbohydrate metabolism , insulin receptor , insulin resistance
Glycogen synthesis is a critical metabolic function of the endometrium to prepare for successful implantation and sustain embryo development. Yet, regulation of endometrial carbohydrate metabolism is poorly characterized. Whereas glycogen synthesis is attributed to progesterone, we previously found that the metabolic B isoform of the insulin receptor is maximally expressed in secretory-phase endometrium, indicating a potential role of insulin in glucose metabolism.
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