The second phase of insulin secretion in non-diabetic islet-grafted recipients is altered and can predict graft outcome | Zendy

Orianne Villard | Zendy; J.F. Brun | Zendy; Lisa Bories | Zendy; Nicolas Molinari | Zendy; PierreYves Benhamou | Zendy; Thierry Berney | Zendy; Anne Wojtusciszyn | Zendy

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The second phase of insulin secretion in non-diabetic islet-grafted recipients is altered and can predict graft outcome

Author(s) -

Orianne Villard,

J.F. Brun,

Lisa Bories,

Nicolas Molinari,

PierreYves Benhamou,

Thierry Berney,

Anne Wojtusciszyn

Publication year - 2018

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2017-01342

Subject(s) - insulin , diabetes mellitus , islet , medicine , type 2 diabetes , endocrinology , transplantation , type 1 diabetes , insulin sensitivity , insulin resistance

Islet transplantation (IT) can treat patients with severely unstable type 1 diabetes. Prehepatic kinetics of insulin secretion (ISec) in two phases can be calculated by C-peptide levels during meal tests. We proposed to describe the ISec profile after a mixed-meal tolerance test (MMTT) in IT recipients and to determine whether the calculated ISec indexes can predict graft outcome.

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