Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma | Zendy

Silviu Sbiera | Zendy; Iuliu Sbiera | Zendy; Carmen Ruggiero | Zendy; Mabrouka Doghman | Zendy; Esther Korpershoek | Zendy; Ronald R. de Krijger | Zendy; Hester Ettaieb | Zendy; Harm R. Haak | Zendy; Marco Volante | Zendy; Mauro Papotti | Zendy; Giuseppe Reimondo | Zendy; Massimo Terzolo | Zendy; Michaela Luconi | Zendy; Gabriella Nesi | Zendy; Massimo Mannelli | Zendy; Rossella Libé | Zendy; Bruno Ragazzon | Zendy; Guillaume Assié | Zendy; Jérôme Bertherat | Zendy; Barbara Altieri | Zendy; Guido Fadda | Zendy; Natalie Rogowski-Lehmann | Zendy; Martín Reincke | Zendy; Felix Beuschlein | Zendy; Martin Faßnacht | Zendy; Enzo Lalli | Zendy

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Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma

Author(s) -

Silviu Sbiera,

Iuliu Sbiera,

Carmen Ruggiero,

Mabrouka Doghman,

Esther Korpershoek,

Ronald R. de Krijger,

Hester Ettaieb,

Harm R. Haak,

Marco Volante,

Mauro Papotti,

Giuseppe Reimondo,

Massimo Terzolo,

Michaela Luconi,

Gabriella Nesi,

Massimo Mannelli,

Rossella Libé,

Bruno Ragazzon,

Guillaume Assié,

Jérôme Bertherat,

Barbara Altieri,

Guido Fadda,

Natalie Rogowski-Lehmann,

Martín Reincke,

Felix Beuschlein,

Martin Faßnacht,

Enzo Lalli

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2017-00984

Subject(s) - adrenocortical carcinoma , malignancy , immunohistochemistry , medicine , oncology , pathology , biology , endocrinology

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with overall poor prognosis. The Ki67 labeling index (LI) has a major prognostic role in localized ACC after complete resection, but its estimates may suffer from considerable intra- and interobserver variability. VAV2 overexpression induced by increased Steroidogenic Factor-1 dosage is an essential factor driving ACC tumor cell invasion.

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