AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome | Zendy

Michael OʼReilly | Zendy; Punith Kempegowda | Zendy; Mark D. Walsh | Zendy; Angela E. Taylor | Zendy; Konstantinos Manolopoulos | Zendy; J. William Allwood | Zendy; Robert K. Semple | Zendy; Daniel Hebenstreit | Zendy; Warwick B. Dunn | Zendy; Jeremy Tomlinson | Zendy; Wiebke Arlt | Zendy

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AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome

Author(s) -

Michael OʼReilly,

Punith Kempegowda,

Mark D. Walsh,

Angela E. Taylor,

Konstantinos Manolopoulos,

J. William Allwood,

Robert K. Semple,

Daniel Hebenstreit,

Warwick B. Dunn,

Jeremy Tomlinson,

Wiebke Arlt

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2017-00947

Subject(s) - polycystic ovary , adipose tissue , endocrinology , medicine , androgen , insulin resistance , adipocyte , androgen excess , lipolysis , testosterone (patch) , biology , lipotoxicity , dihydrotestosterone , insulin , hormone

Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. We hypothesized that adipose tissue is an important site linking androgen activation and metabolic dysfunction in PCOS.

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