Fetal Exposure to High Maternal Thyroid Hormone Levels Causes Central Resistance to Thyroid Hormone in Adult Humans and Mice | Zendy

Panudda Srichomkwun | Zendy; João Anselmo | Zendy; Xiao-Hui Liao | Zendy; Georg Sebastian Hönes | Zendy; Lars C. Moeller | Zendy; Manuela AlonsoSampedro | Zendy; Roy E. Weiss | Zendy; Alexandra M. Dumitrescu | Zendy; Samuel Refetoff | Zendy

Open Access

Fetal Exposure to High Maternal Thyroid Hormone Levels Causes Central Resistance to Thyroid Hormone in Adult Humans and Mice

Author(s) -

Panudda Srichomkwun,

João Anselmo,

Xiao-Hui Liao,

Georg Sebastian Hönes,

Lars C. Moeller,

Manuela AlonsoSampedro,

Roy E. Weiss,

Alexandra M. Dumitrescu,

Samuel Refetoff

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2017-00019

Subject(s) - endocrinology , medicine , thyroid , hormone , deiodinase , euthyroid , triiodothyronine , in utero , dio2 , hypothalamic–pituitary–thyroid axis , anterior pituitary , biology , fetus , pregnancy , genetics

Fetuses exposed to the high thyroid hormone (TH) levels of mothers with resistance to thyroid hormone beta (RTH-β), due to mutations in the THRB gene, have low birth weight and suppressed TSH.

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