Pulsatile GnRH Therapy May Restore Hypothalamus–Pituitary–Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial | Zendy

Junjie Zheng | Zendy; Jiangfeng Mao | Zendy; Hongli Xu | Zendy; Xi Wang | Zendy; Bingkun Huang | Zendy; Zhaoxiang Liu | Zendy; Mingxuan Cui | Zendy; Shuyu Xiong | Zendy; Wanlu Ma | Zendy; Le Min | Zendy; Ursula B. Kaiser | Zendy; Min Nie | Zendy; Xueyan Wu | Zendy

Open Access

Pulsatile GnRH Therapy May Restore Hypothalamus–Pituitary–Testis Axis Function in Patients With Congenital Combined Pituitary Hormone Deficiency: A Prospective, Self-Controlled Trial

Author(s) -

Junjie Zheng,

Jiangfeng Mao,

Hongli Xu,

Xi Wang,

Bingkun Huang,

Zhaoxiang Liu,

Mingxuan Cui,

Shuyu Xiong,

Wanlu Ma,

Le Min,

Ursula B. Kaiser,

Min Nie,

Xueyan Wu

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3990

Subject(s) - pulsatile flow , hypothalamus , medicine , endocrinology , pituitary gland , hormone

The effectiveness of pulsatile gonadotropin-releasing hormone (GnRH) therapy in patients with congenital combined pituitary hormone deficiency (CCPHD) has not been investigated because of the limited number of patients, as well as these patients' presumed pituitary hypoplasia, poor gonadotrophic cell reserve, and impaired gonadotrophic response to GnRH.

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