Open AccessInterleukin-1 Antagonism Decreases Cortisol Levels in Obese Individuals
Author(s) -
Sandrine Urwyler,
Philipp Schüetz,
Fahim Ebrahimi,
Marc Y. Donath,
Mirjam ChristCrain
Publication year - 2017
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-3931
Subject(s) - medicine , endocrinology , body mass index , morning , metabolic syndrome , obesity , hydrocortisone
Increased cortisol levels in obesity may contribute to the associated metabolic syndrome. In obesity, the activated innate immune system leads to increased interleukin (IL)-1β, which is known to stimulate the release of adrenocorticotropin hormone (ACTH).
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