Effect of Moxonidine on the Aldosterone/Renin Ratio in Healthy Male Volunteers | Zendy

Ashraf Ahmed | Zendy; Richard D. Gordon | Zendy; Gregory J. Ward | Zendy; Martin Wolley | Zendy; Brett McWhinney | Zendy; Jacobus Ungerer | Zendy; Michael Stowasser | Zendy

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Effect of Moxonidine on the Aldosterone/Renin Ratio in Healthy Male Volunteers

Author(s) -

Ashraf Ahmed,

Richard D. Gordon,

Gregory J. Ward,

Martin Wolley,

Brett McWhinney,

Jacobus Ungerer,

Michael Stowasser

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3821

Subject(s) - aldosterone , moxonidine , endocrinology , medicine , plasma renin activity , renin–angiotensin system , creatinine , primary aldosteronism , blood pressure , chemistry , receptor , agonist

The most popular screening test for primary aldosteronism is the plasma aldosterone/renin ratio (ARR). Medications, dietary sodium, posture, and time of day all affect renin and aldosterone levels and can result in false-negative or false-positive ARRs if not controlled. Most antihypertensive medications affect the ARR and can interfere with interpretation of results. To our knowledge, no study has been undertaken to evaluate the effects of moxonidine on the ARR.

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