Vitamin D Reduces Oxidative Stress–Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts | Zendy

Jie Xu | Zendy; Xiu-Yue Jia | Zendy; Yang Gu | Zendy; David F. Lewis | Zendy; Xin Gu | Zendy; Yuping Wang | Zendy

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Vitamin D Reduces Oxidative Stress–Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts

Author(s) -

Jie Xu,

Xiu-Yue Jia,

Yang Gu,

David F. Lewis,

Xin Gu,

Yuping Wang

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3753

Subject(s) - trophoblast , downregulation and upregulation , enos , oxidative stress , endocrinology , preeclampsia , medicine , placenta , chemistry , andrology , biology , nitric oxide , nitric oxide synthase , fetus , biochemistry , pregnancy , genetics , gene

Increased microparticle (MP) shedding by placental trophoblasts contributes to maternal vascular inflammatory response and endothelial dysfunction in preeclampsia. Vitamin D has beneficial effects in pregnancy; however, its effect on trophoblast MP release has not been investigated.

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