Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers | Zendy

Kristy A. Brown | Zendy; Neil M. Iyengar | Zendy; Xi Kathy Zhou | Zendy; Ayca Gucalp | Zendy; Kotha Subbaramaiah | Zendy; Hanhan Wang | Zendy; Dilip D. Giri | Zendy; Monica Morrow | Zendy; Domenick J. Falcone | Zendy; Nils K. Wendel | Zendy; Lisle Winston | Zendy; Michaël Pollak | Zendy; Anneloor Dierickx | Zendy; Clifford A. Hudis | Zendy; Andrew J. Dannenberg | Zendy

Open Access

Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers

Author(s) -

Kristy A. Brown,

Neil M. Iyengar,

Xi Kathy Zhou,

Ayca Gucalp,

Kotha Subbaramaiah,

Hanhan Wang,

Dilip D. Giri,

Monica Morrow,

Domenick J. Falcone,

Nils K. Wendel,

Lisle Winston,

Michaël Pollak,

Anneloor Dierickx,

Clifford A. Hudis,

Andrew J. Dannenberg

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3606

Subject(s) - aromatase , medicine , endocrinology , breast cancer , leptin , adiponectin , estrogen , menopause , body mass index , insulin resistance , cancer , obesity

Most estrogen-dependent breast cancers occur after menopause, despite low levels of circulating estrogens. Breast expression of the estrogen-biosynthetic enzyme, aromatase, is proposed to drive breast cancer development after menopause. However, the effects of menopause on breast aromatase expression are unknown.

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