Third Trimester Estrogens and Maternal Breast Cancer: Prospective Evidence | Zendy

Barbara A. Cohn | Zendy; Piera M. Cirillo | Zendy; BILL R. HOPPER | Zendy; Pentti K. Siiteri | Zendy

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Third Trimester Estrogens and Maternal Breast Cancer: Prospective Evidence

Author(s) -

Barbara A. Cohn,

Piera M. Cirillo,

BILL R. HOPPER,

Pentti K. Siiteri

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3476

Subject(s) - medicine , breast cancer , estriol , hazard ratio , obstetrics , pregnancy , prospective cohort study , gynecology , estrone , confidence interval , cancer , estrogen , biology , genetics

Full-term pregnancy is associated with a transient increase and life-time decrease in maternal breast cancer risk. Estrone (E1), estradiol (E2), and estriol (E3) are in high concentration during the third trimester. E1 and E2 metabolism produces carcinogenic intermediaries, and E3 metabolism does not.

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