CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism | Zendy

İhsan Turan | Zendy; B. Ian Hutchins | Zendy; Bülent Hacıhamdioğlu | Zendy; Leman Damla Kotan | Zendy; Fatih Gürbüz | Zendy; Ayça Ulubay | Zendy; Eda Mengen | Zendy; Bilgin Yüksel | Zendy; Susan Wray | Zendy; A. Kemal Topaloğlu | Zendy

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CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism

Author(s) -

İhsan Turan,

B. Ian Hutchins,

Bülent Hacıhamdioğlu,

Leman Damla Kotan,

Fatih Gürbüz,

Ayça Ulubay,

Eda Mengen,

Bilgin Yüksel,

Susan Wray,

A. Kemal Topaloğlu

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3391

Subject(s) - hypogonadotropic hypogonadism , medicine , genetics , biology , hormone

Gonadotropin-releasing hormone neurons originate outside the central nervous system in the olfactory placode and migrate into the central nervous system, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired migration of GnRH neurons but not of olfactory receptor neurons.

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