The Hepatic Protection Effects of Hepassocin in Hyperglycemic Crisis | Zendy

Horng-Yih Ou | Zendy; HungTsung Wu | Zendy; Ching-Han Lin | Zendy; YeFong Du | Zendy; CheYuan Hu | Zendy; HaoChang Hung | Zendy; Pansee Wu | Zendy; HungYuan Li | Zendy; ShuHuei Wang | Zendy; ChihJen Chang | Zendy

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The Hepatic Protection Effects of Hepassocin in Hyperglycemic Crisis

Author(s) -

Horng-Yih Ou,

HungTsung Wu,

Ching-Han Lin,

YeFong Du,

CheYuan Hu,

HaoChang Hung,

Pansee Wu,

HungYuan Li,

ShuHuei Wang,

ChihJen Chang

Publication year - 2017

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3287

Subject(s) - endocrinology , medicine , hepatocyte , reactive oxygen species , streptozotocin , signal transduction , oxidative stress , superoxide dismutase , chemistry , biology , diabetes mellitus , microbiology and biotechnology , biochemistry , in vitro

High glucose generates reactive oxygen species (ROS) and contributes to glucotoxicity in hepatocytes, and hyperglycemia causes structural and functional damage to the liver. However, only a mild hepatic dysfunction was observed in subjects with hyperglycemic crisis, implying a factor exists to exert a hepatic protective effect. Hepassocin is a hepatokine that modulates the proliferation and metabolism of hepatocytes and also exerts protective activity in liver injury. However, its role in hyperglycemic crisis-induced hepatic dysfunction remains unknown.

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