11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome | Zendy

Michael OʼReilly | Zendy; Punith Kempegowda | Zendy; Carl Jenkinson | Zendy; Angela E. Taylor | Zendy; Jonathan L. Quanson | Zendy; KarlHeinz Storbeck | Zendy; Wiebke Arlt | Zendy

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11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome

Author(s) -

Michael OʼReilly,

Punith Kempegowda,

Carl Jenkinson,

Angela E. Taylor,

Jonathan L. Quanson,

KarlHeinz Storbeck,

Wiebke Arlt

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-3285

Subject(s) - endocrinology , medicine , polycystic ovary , androgen excess , androgen , interquartile range , context (archaeology) , testosterone (patch) , hyperandrogenism , chemistry , insulin resistance , insulin , biology , hormone , paleontology

Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to androgen excess in women with PCOS.

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