Progesterone Receptors and Proliferation of the Endometrium in Obese Women With Polycystic Ovary Syndrome—A Lifestyle Intervention Study
Author(s) -
Mariana Paulson,
Lena Sahlin,
Angelica Lindén Hirschberg
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-3155
Subject(s) - medicine , polycystic ovary , endocrinology , endometrium , anovulation , immunostaining , progesterone receptor , ovulation , follicular phase , endometrial cancer , estrogen receptor , obesity , immunohistochemistry , cancer , insulin resistance , hormone , breast cancer
Polycystic ovary syndrome (PCOS) is associated with increased risk of endometrial cancer. This is usually explained by chronic anovulation and deficient progesterone activity. However, the role of progesterone receptors (PRs) in endometrial proliferation is unclear.
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