Histopathological classification of cross-sectional image negative hyperaldosteronism | Zendy

Yuto Yamazaki | Zendy; Yasuhiro Nakamura | Zendy; Kei Omata | Zendy; Kazue Ise | Zendy; Yuta Tezuka | Zendy; Yoshikiyo Ono | Zendy; Ryo Morimoto | Zendy; Yukinaga Nozawa | Zendy; Celso E. Gómez-Sánchez | Zendy; Scott A. Tomlins | Zendy; William E. Rainey | Zendy; Sadayoshi Ito | Zendy; Fumitoshi Satoh | Zendy; Hironobu Sasano | Zendy

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Histopathological classification of cross-sectional image negative hyperaldosteronism

Author(s) -

Yuto Yamazaki,

Yasuhiro Nakamura,

Kei Omata,

Kazue Ise,

Yuta Tezuka,

Yoshikiyo Ono,

Ryo Morimoto,

Yukinaga Nozawa,

Celso E. Gómez-Sánchez,

Scott A. Tomlins,

William E. Rainey,

Sadayoshi Ito,

Fumitoshi Satoh,

Hironobu Sasano

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2986

Subject(s) - hyperaldosteronism , aldosterone synthase , aldosterone , germline mutation , hyperplasia , medicine , biology , pathology , immunohistochemistry , endocrinology , mutation , renin–angiotensin system , gene , genetics , blood pressure

Approximately half of patients with primary aldosteronism (PA) have clinically evident disease according to clinical (hypertension) and/or laboratory (aldosterone and renin levels) findings but do not have nodules detectable in routine cross-sectional imaging. However, the detailed histopathologic, steroidogenic, and pathobiological features of cross-sectional image-negative PA are controversial.

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