Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia | Zendy

Christopher M. Jones | Zendy; Ashwini Mallappa | Zendy; Nicole Reisch | Zendy; Nikolaos Nikolaou | Zendy; Nils Krone | Zendy; Beverly Hughes | Zendy; Donna O’Neil | Zendy; Martin J. Whitaker | Zendy; Jeremy Tomlinson | Zendy; KarlHeinz Storbeck | Zendy; Deborah P. Merke | Zendy; Richard Ross | Zendy; Wiebke Arlt | Zendy

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Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia

Author(s) -

Christopher M. Jones,

Ashwini Mallappa,

Nicole Reisch,

Nikolaos Nikolaou,

Nils Krone,

Beverly Hughes,

Donna O’Neil,

Martin J. Whitaker,

Jeremy Tomlinson,

KarlHeinz Storbeck,

Deborah P. Merke,

Richard Ross,

Wiebke Arlt

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2855

Subject(s) - androstenedione , congenital adrenal hyperplasia , endocrinology , androgen , dehydroepiandrosterone , medicine , context (archaeology) , glucocorticoid , dihydrotestosterone , testosterone (patch) , androgen excess , chemistry , hormone , biology , paleontology , insulin resistance , polycystic ovary , insulin

The classic androgen synthesis pathway proceeds via dehydroepiandrosterone, androstenedione, and testosterone to 5α-dihydrotestosterone. However, 5α-dihydrotestosterone synthesis can also be achieved by an alternative pathway originating from 17α-hydroxyprogesterone (17OHP), which accumulates in congenital adrenal hyperplasia (CAH). Similarly, recent work has highlighted androstenedione-derived 11-oxygenated 19-carbon steroids as active androgens, and in CAH, androstenedione is generated directly from 17OHP. The exact contribution of alternative pathway activity to androgen excess in CAH and its response to glucocorticoid (GC) therapy is unknown.

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