Case Report: Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-related Diabetes | Zendy

Siri Atma W. Greeley | Zendy; Mark C. Zielinski | Zendy; Ananta Poudel | Zendy; Honggang Ye | Zendy; Shivani Berry | Zendy; Jerome B. Taxy | Zendy; David Carmody | Zendy; Donald F. Steiner | Zendy; Louis H. Philipson | Zendy; Jamie Wood | Zendy; Manami Hara | Zendy

Open Access

Case Report: Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-related Diabetes

Author(s) -

Siri Atma W. Greeley,

Mark C. Zielinski,

Ananta Poudel,

Honggang Ye,

Shivani Berry,

Jerome B. Taxy,

David Carmody,

Donald F. Steiner,

Louis H. Philipson,

Jamie Wood,

Manami Hara

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2826

Subject(s) - endocrinology , medicine , insulin , sulfonylurea , glucagon , pancreas , somatostatin , diabetes mellitus , enteroendocrine cell , pancreatic polypeptide , islet , endocrine system , cell , biology , hormone , biochemistry

The most common genetic cause of permanent neonatal diabetes mellitus is activating mutations in KCNJ11, which can usually be treated using oral sulfonylureas (SUs) instead of insulin injections, although some mutations are SU unresponsive. In this work, we provide a report of the pancreatic islet endocrine cell composition and area in a patient with an SU-unresponsive KCNJ11 mutation (p.G334D), in comparison with age-matched controls.

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