Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals | Zendy

Lauren M. Sparks | Zendy; Leanne M. Redman | Zendy; Kevin E. Conley | Zendy; MaryEllen Harper | Zendy; Andrew P. Hodges | Zendy; Alexey M. Eroshkin | Zendy; Sheila R. Costford | Zendy; Meghan Hufstader Gabriel | Zendy; Fanchao Yi | Zendy; Cherie Shook | Zendy; Heather H. Cornnell | Zendy; Éric Ravussin | Zendy; Steven R. Smith | Zendy

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Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals

Author(s) -

Lauren M. Sparks,

Leanne M. Redman,

Kevin E. Conley,

MaryEllen Harper,

Andrew P. Hodges,

Alexey M. Eroshkin,

Sheila R. Costford,

Meghan Hufstader Gabriel,

Fanchao Yi,

Cherie Shook,

Heather H. Cornnell,

Éric Ravussin,

Steven R. Smith

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2742

Subject(s) - in vivo , mitochondrion , muscle biopsy , mitochondrial dna , biology , medicine , hsp70 , oxidative stress , oxidative phosphorylation , endocrinology , heat shock protein , chemistry , biopsy , microbiology and biotechnology , gene , biochemistry , genetics

Reduced mitochondrial coupling (ATP/O 2 [P/O]) is associated with sedentariness and insulin resistance. Interpreting the physiological relevance of P/O measured in vitro is challenging.

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