Beneficial Effects of GH in Young Adults With Prader-Willi Syndrome: A 2-Year Crossover Trial | Zendy

Renske Kuppens | Zendy; Nienke Bakker | Zendy; Elbrich P. C. Siemensma | Zendy; Roderick F. A. Tummers-de Lind van Wijngaarden | Zendy; Stephany Donze | Zendy; Dederieke A. M. Festen | Zendy; Janiëlle A. E. M. van Alfenvan der Velden | Zendy; Theo Stijnen | Zendy; Anita Hokken-Koelega | Zendy

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Beneficial Effects of GH in Young Adults With Prader-Willi Syndrome: A 2-Year Crossover Trial

Author(s) -

Renske Kuppens,

Nienke Bakker,

Elbrich P. C. Siemensma,

Roderick F. A. Tummers-de Lind van Wijngaarden,

Stephany Donze,

Dederieke A. M. Festen,

Janiëlle A. E. M. van Alfenvan der Velden,

Theo Stijnen,

Anita Hokken-Koelega

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2594

Subject(s) - placebo , medicine , crossover study , lean body mass , endocrinology , discontinuation , body mass index , adverse effect , obesity , trunk , body weight , alternative medicine , pathology , ecology , biology

Patients with Prader-Willi syndrome (PWS) are severely at risk to develop morbid obesity, diabetes mellitus type 2, and cardiovascular disease, leading to high mortality. They have an increased fat mass (FM) and decreased lean body mass (LBM). During childhood, GH treatment counteracts the natural course of increasing obesity. Discontinuation of GH treatment at attainment of adult height (AH) might deteriorate their improved clinical condition, whereas continuation might benefit them.

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