Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study | Zendy

Henrike Knacke | Zendy; Maik Pietzner | Zendy; Kieu Trinh | Zendy; Werner RömischMargl | Zendy; Gabi Kastenmüller | Zendy; Uwe Völker | Zendy; Henry Völzke | Zendy; Jan Krumsiek | Zendy; Anna Artati | Zendy; Henri Wallaschofski | Zendy; Matthias Nauck | Zendy; Karsten Suhre | Zendy; Jerzy Adamski | Zendy; Nele Friedrich | Zendy

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Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study

Author(s) -

Henrike Knacke,

Maik Pietzner,

Kieu Trinh,

Werner RömischMargl,

Gabi Kastenmüller,

Uwe Völker,

Henry Völzke,

Jan Krumsiek,

Anna Artati,

Henri Wallaschofski,

Matthias Nauck,

Karsten Suhre,

Jerzy Adamski,

Nele Friedrich

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2588

Subject(s) - metabolomics , metabolome , metabolite , endocrinology , medicine , urine , lipid metabolism , metabolism , biology , bioinformatics

IGF-1 is known for its various physiological and severe pathophysiological effects on human metabolism; however, underlying molecular mechanisms still remain unsolved. To reveal possible molecular mechanisms mediating these effects, for the first time, we associated serum IGF-1 levels with multifluid untargeted metabolomics data.

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