Germline polymorphisms of the VEGF-pathway predict recurrence in non-advanced differentiated thyroid cancer
Author(s) -
Vincenzo Marotta,
Concetta Sciammarella,
Mario Capasso,
Alessandro Testori,
Claudia Pivonello,
Maria Grazia Chiofalo,
Claudio Gambardella,
Marica Grasso,
A Antonino,
Annamaria Annunziata,
Paolo Emidio Macchia,
Rosario Pivonello,
Luigi Santini,
Gerardo Botti,
Simona Losito,
Luciano Pezzullo,
Annamaria Colao,
Antongiulio Faggiano
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-2555
Subject(s) - single nucleotide polymorphism , medicine , thyroid cancer , genotype , odds ratio , gastroenterology , oncology , confidence interval , breast cancer , angiogenesis , vascular endothelial growth factor , pathology , cancer , biology , vegf receptors , genetics , gene
Tumor angiogenesis is determined by host genetic background rather than environment. Germline single nucleotide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) pathway have demonstrated prognostic value in different tumors.
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