Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity | Zendy

Stefan Lutz | Zendy; Andreas Peter | Zendy; Fausto Machicao | Zendy; Apostolia Lamprinou | Zendy; Jürgen Machann | Zendy; Fritz Schick | Zendy; Ingmar Königsrainer | Zendy; Alfred Königsrainer | Zendy; Andreas Fritsche | Zendy; Harald Staiger | Zendy; HansUlrich Häring | Zendy; Norbert Stefan | Zendy; Kοnstantinos Kantartzis | Zendy

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Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity

Author(s) -

Stefan Lutz,

Andreas Peter,

Fausto Machicao,

Apostolia Lamprinou,

Jürgen Machann,

Fritz Schick,

Ingmar Königsrainer,

Alfred Königsrainer,

Andreas Fritsche,

Harald Staiger,

HansUlrich Häring,

Norbert Stefan,

Kοnstantinos Kantartzis

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2498

Subject(s) - single nucleotide polymorphism , endocrinology , medicine , minor allele frequency , insulin resistance , nonalcoholic fatty liver disease , 11β hydroxysteroid dehydrogenase type 1 , allele , odds ratio , intra abdominal fat , obesity , biology , fatty liver , genotype , gene , genetics , disease , dehydrogenase , enzyme , biochemistry , visceral fat

Acute pharmacological inhibition of 11β-hydroxysteroid-dehydrogenase 1 (11β-HSD1), which converts cortisone into the much more potent cortisol in peripheral tissues, results in reduction of total, visceral, and liver fat but not insulin resistance. We now investigated whether lifelong alterations of 11β-HSD1 activity similarly affect these cardiometabolic risk parameters by studying single-nucleotide polymorphisms (SNPs) in the 11β-HSD1-coding gene (HSD11B1).

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