Open AccessIncreased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes
Author(s) -
Abu Saleh Md Moin,
Sangeeta Dhawan,
Megan Cory,
Peter C. Butler,
Robert A. Rizza,
Alexandra E. Butler
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-2496
Subject(s) - endocrinology , medicine , type 2 diabetes , beta cell , diabetes mellitus , pancreas , degranulation , enteroendocrine cell , hormone , biology , endocrine system , insulin , islet , receptor
It has been suggested that beta cell loss in type 2 diabetes (T2D) may be due to beta cell degranulation and/or altered cell identity. While shown to have a minor role in obese T2D, this has not been evaluated in lean T2D.
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