A Variant in theBACH2Gene Is Associated With Susceptibility to Autoimmune Addison’s Disease in Humans | Zendy

Agnieszka Pazderska | Zendy; Bergithe E Oftedal | Zendy; Catherine Napier | Zendy; Holly F. Ainsworth | Zendy; Eystein S. Husebye | Zendy; Heather J. Cordell | Zendy; Simon H. S. Pearce | Zendy; Anna L. Mitchell | Zendy

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A Variant in theBACH2Gene Is Associated With Susceptibility to Autoimmune Addison’s Disease in Humans

Author(s) -

Agnieszka Pazderska,

Bergithe E Oftedal,

Catherine Napier,

Holly F. Ainsworth,

Eystein S. Husebye,

Heather J. Cordell,

Simon H. S. Pearce,

Anna L. Mitchell

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2368

Subject(s) - odds ratio , single nucleotide polymorphism , medicine , snp , cohort , genotype , minor allele frequency , allele , confidence interval , case control study , polymorphism (computer science) , taqman , immunology , gastroenterology , genetics , gene , biology , real time polymerase chain reaction

Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation in its gene has been associated with a number of autoimmune conditions.

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