GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome | Zendy

Liron Danielpur | Zendy; YangSung Sohn | Zendy; Ola Karmi | Zendy; Chen Fogel | Zendy; Adar Zinger | Zendy; Abdulsalam AbuLibdeh | Zendy; Tal Israeli | Zendy; Yael Riahi | Zendy; Orit Pappo | Zendy; Ruth Birk | Zendy; David Zangen | Zendy; Ron Mittler | Zendy; Zvi-Ioav Cabantchik | Zendy; Erol Cerasi | Zendy; Rachel Nechushtai | Zendy; Gil Leibowitz | Zendy

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GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome

Author(s) -

Liron Danielpur,

YangSung Sohn,

Ola Karmi,

Chen Fogel,

Adar Zinger,

Abdulsalam AbuLibdeh,

Tal Israeli,

Yael Riahi,

Orit Pappo,

Ruth Birk,

David Zangen,

Ron Mittler,

Zvi-Ioav Cabantchik,

Erol Cerasi,

Rachel Nechushtai,

Gil Leibowitz

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2240

Subject(s) - endocrinology , medicine , insulin , mitochondrion , type 2 diabetes , chemistry , exenatide , insulin resistance , context (archaeology) , diabetes mellitus , biology , biochemistry , paleontology

Type 2 Wolfram syndrome (T2-WFS) is a neuronal and β-cell degenerative disorder caused by mutations in the CISD2 gene. The mechanisms underlying β-cell dysfunction in T2-WFS are not known, and treatments that effectively improve diabetes in this context are lacking.

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