Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus | Zendy

Anna J. Anderson | Zendy; Ruth Andrew | Zendy; Natalie Homer | Zendy; Gregory C. Jones | Zendy; Kenneth Smith | Zendy; Dawn E. W. Livingstone | Zendy; Brian R. Walker | Zendy; Roland H. Stimson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus

Author(s) -

Anna J. Anderson,

Ruth Andrew,

Natalie Homer,

Gregory C. Jones,

Kenneth Smith,

Dawn E. W. Livingstone,

Brian R. Walker,

Roland H. Stimson

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-2069

Subject(s) - metformin , medicine , endocrinology , diabetes mellitus , placebo , context (archaeology) , type 2 diabetes , hydrocortisone , biology , paleontology , alternative medicine , pathology

The mechanism of action of metformin remains unclear. Given the regulation of the cortisol-regenerating enzyme 11βhydroxysteroid dehydrogenase 1 (11βHSD1) by insulin and the limited efficacy of selective 11βHSD1 inhibitors to lower blood glucose when co-prescribed with metformin, we hypothesized that metformin reduces 11βHSD1 activity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research