Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans | Zendy

Meena Asmar | Zendy; Lene Simonsen | Zendy; Ali Asmar | Zendy; Jens J. Holst | Zendy; Flemming Dela | Zendy; Jens Bülow | Zendy

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Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans

Author(s) -

Meena Asmar,

Lene Simonsen,

Ali Asmar,

Jens J. Holst,

Flemming Dela,

Jens Bülow

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1933

Subject(s) - endocrinology , medicine , adipose tissue , insulin , glucose clamp technique , hyperinsulinemia , gastric inhibitory polypeptide , glucose uptake , postprandial , white adipose tissue , chemistry , triglyceride , somatostatin , hyperinsulinism , glucagon , insulin resistance , pancreatic hormone , biology , cholesterol

Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increases blood flow and triglyceride (TAG) clearance in subcutaneous (sc) abdominal adipose tissue in lean humans. The present experiments were performed to further investigate the role of insulin for the vasoactive effect of GIP in adipose tissue metabolism and whether the vasodilatory effect of GIP is dependent on C-peptide.

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