Papillary Thyroid Carcinoma With Rare Exon 15 BRAF Mutation Has Indolent Behavior: A Single-Institution Experience | Zendy

Liborio Torregrossa | Zendy; David Viola | Zendy; Elisa Sensi | Zendy; Mirella Giordano | Zendy; Paolo Piaggi | Zendy; Cristina Romei | Zendy; Gabriele Materazzi | Zendy; Paolo Miccoli | Zendy; Rossella Elisei | Zendy; Fulvio Basolo | Zendy

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Papillary Thyroid Carcinoma With Rare Exon 15 BRAF Mutation Has Indolent Behavior: A Single-Institution Experience

Author(s) -

Liborio Torregrossa,

David Viola,

Elisa Sensi,

Mirella Giordano,

Paolo Piaggi,

Cristina Romei,

Gabriele Materazzi,

Paolo Miccoli,

Rossella Elisei,

Fulvio Basolo

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1775

Subject(s) - exon , thyroid carcinoma , medicine , v600e , lymph node , clinical significance , pathology , mutation , stage (stratigraphy) , carcinoma , thyroid , cancer research , oncology , biology , gene , genetics , paleontology

Approximately 40% of papillary thyroid carcinomas (PTCs) harbor the BRAF V600E mutation, which is significantly associated with the advanced clinicopathological features of PTC at diagnosis, a higher recurrence rate, and disease-related mortality. BRAF alterations other than V600E are less common in PTC, and their clinical significance remains to be established.

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