Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy | Zendy

Gabriel H. Wolfson | Zendy; Enrique Vargas | Zendy; Vaughn A. Browne | Zendy; Lorna G. Moore | Zendy; Colleen G. Julian | Zendy

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Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy

Author(s) -

Gabriel H. Wolfson,

Enrique Vargas,

Vaughn A. Browne,

Lorna G. Moore,

Colleen G. Julian

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1767

Subject(s) - erythropoietin , erythropoietin receptor , pregnancy , preeclampsia , medicine , endocrinology , receptor , gestation , pathological , biology , genetics

An imbalance of proangiogenic and antiangiogenic factors is thought to induce the widespread vascular dysfunction characteristic of preeclampsia (PreE). Erythropoietin (Epo), a pleiotropic cytokine, has important angiogenic and vasoactive properties; however, its contribution to maternal vascular dysfunction in PreE is unknown.

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