PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas | Zendy

Yara Rhayem | Zendy; Luis Gustavo PerezRivas | Zendy; Anna Dietz | Zendy; Kerstin Bathon | Zendy; Christian Gebhard | Zendy; Anna Riester | Zendy; Brigitte Mauracher | Zendy; Celso E. Gómez-Sánchez | Zendy; Graeme Eisenhofer | Zendy; Thomas Schwarzmayr | Zendy; Davide Calebiro | Zendy; Tim M. Strom | Zendy; Martín Reincke | Zendy; Felix Beuschlein | Zendy

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PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas

Author(s) -

Yara Rhayem,

Luis Gustavo PerezRivas,

Anna Dietz,

Kerstin Bathon,

Christian Gebhard,

Anna Riester,

Brigitte Mauracher,

Celso E. Gómez-Sánchez,

Graeme Eisenhofer,

Thomas Schwarzmayr,

Davide Calebiro,

Tim M. Strom,

Martín Reincke,

Felix Beuschlein

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1700

Subject(s) - endocrinology , medicine , aldosterone , germline mutation , biology , somatic cell , context (archaeology) , mutation , genetics , gene , paleontology

Somatic mutations have been found causative for endocrine autonomy in aldosterone-producing adenomas (APAs). Whereas mutations of PRKACA (catalytic subunit of protein kinase A) have been identified in cortisol-producing adenomas, the presence of PRKACA variants in APAs is unknown, especially in those that display cosecretion of cortisol.

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