Cushing in a Leaf: Endocrine Disruption From a Natural Remedy | Zendy

Chiara Martini | Zendy; Eva Zanchetta | Zendy; Mauro Di Ruvo | Zendy; Alessandro Nalesso | Zendy; Marialberta Battocchio | Zendy; Erica Gentilin | Zendy; Ettore C. degli Uberti | Zendy; Roberto Vettor | Zendy; Maria Chiara Zatelli | Zendy

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Cushing in a Leaf: Endocrine Disruption From a Natural Remedy

Author(s) -

Chiara Martini,

Eva Zanchetta,

Mauro Di Ruvo,

Alessandro Nalesso,

Marialberta Battocchio,

Erica Gentilin,

Ettore C. degli Uberti,

Roberto Vettor,

Maria Chiara Zatelli

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1490

Subject(s) - glucocorticoid receptor , glucocorticoid , mifepristone , dexamethasone , medicine , endocrinology , acth receptor , adrenocorticotropic hormone , pharmacology , biology , hormone , pregnancy , genetics

Information regarding the safety of herbal drugs is often not reported. We describe the case of a 65-year-old woman referred to us for a iatrogenic hypercortisolism, who denied any previous steroid consumption. She reported only a chronic application of a phytocosmetic cream, containing ethanol extract of the Cardiospermum halicacabum (CH) plant. Adrenal insufficiency occurred after the cream application was stopped. CH is used in traditional and Western medicine for its documented anti-inflammatory properties. Once the presence of synthetic glucocorticoids was ruled out in the phytocosmetic product, we investigated whether and how its chronic application could have caused the iatrogenic hypercortisolism.

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