Open AccessCirculating MKRN3 Levels Decline During Puberty in Healthy Boys
Author(s) -
Alexander S Busch,
Casper P. Hagen,
Kristian Almstrup,
Anders Juul
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-1488
Subject(s) - endocrinology , medicine , precocious puberty , central precocious puberty , population , hormone , environmental health
Initiation and progression of puberty requires concerted action of hypothalamic activating and inhibiting factors. Recently, cases of familial central precocious puberty have been linked to loss-of-function mutations of makorin RING-finger protein 3 (MKRN3) indicating a pivotal inhibitory role of the protein on GnRH secretion.
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