Measurement of Salivary Cortisone to Assess the Adequacy of Hydrocortisone Replacement | Zendy

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Measurement of Salivary Cortisone to Assess the Adequacy of Hydrocortisone Replacement

Author(s) -

Hershel Raff

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1228

Subject(s) - cortisone , hydrocortisone , medicine , saliva , adrenal insufficiency , endocrinology , salivary gland , corticosteroid

This Commentary discusses the study of Debono et al (19) and focuses on the potential use of multiple salivary cortisone measurements to evaluate the adequacy of hydrocortisone replacement therapy. Salivary cortisone, typically measured using liquid chromatography-tandem mass spectrometry, accurately reflects plasma free cortisol because of the expression of 11-β -hydroxysteroid dehydrogenase in the salivary gland. Debono et al showed that multiple, sequential salivary cortisone measurements obtained over a 12-hour period correlated with plasma free cortisol in subjects receiving intravenous or oral hydrocortisone (authentic cortisol).

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