Cholecystokinin-Induced Gallbladder Emptying and Metformin Elicit Additive Glucagon-Like Peptide-1 Responses
Author(s) -
Ulrich Rohde,
David P. Sonne,
Mikkel Christensen,
Morten Hansen,
Andreas Brønden,
Signe Toräng,
Jens F. Rehfeld,
Jens J. Holst,
Tina Vilsbøll,
Filip K. Knop
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-1133
Subject(s) - medicine , metformin , cholecystokinin , gastric emptying , endocrinology , gallbladder , glucagon like peptide 1 , gastrointestinal hormone , glucagon , diabetes mellitus , insulin , type 2 diabetes , peptide hormone , stomach , hormone , receptor
Bile acids have been suggested to mediate glucagon-like peptide-1 (GLP-1) secretion. Metformin, too, has been shown to increase GLP-1 levels. The effect of gallbladder emptying, metformin, or a combination has, however, never been studied.
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