Topical Sodium Thiosulfate: A Treatment for Calcifications in Hyperphosphatemic Familial Tumoral Calcinosis? | Zendy

Jérémy Jost | Zendy; Claire Bahans | Zendy; Marie Courbebaisse | Zendy; Tú-Anh Tran | Zendy; Agnès Linglart | Zendy; Karelle Bénistan | Zendy; Anne Lienhardt | Zendy; Hadile Mutar | Zendy; Elodie Pfender | Zendy; Voa Ratsimbazafy | Zendy; Vincent Guigonis | Zendy

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Topical Sodium Thiosulfate: A Treatment for Calcifications in Hyperphosphatemic Familial Tumoral Calcinosis?

Author(s) -

Jérémy Jost,

Claire Bahans,

Marie Courbebaisse,

Tú-Anh Tran,

Agnès Linglart,

Karelle Bénistan,

Anne Lienhardt,

Hadile Mutar,

Elodie Pfender,

Voa Ratsimbazafy,

Vincent Guigonis

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2016-1087

Subject(s) - medicine , hyperphosphatemia , ectopic calcification , tumoral calcinosis , sodium thiosulfate , adverse effect , dermatology , calcification , calcinosis , kidney disease , inorganic chemistry , chemistry

Hyperphosphatemic familial tumoral calcinosis (HFTC) and hyperphosphatemia hyperostosis syndrome (HHS) are rare diseases characterized by hyperphosphatemia and ectopic calcifications or recurrent episodes of diaphysitis. In the setting of metabolic or inflammatory diseases, recent data suggest that systemic administration of sodium thiosulfate (STS) could be effective in the treatment of ectopic calcifications but may also be poorly tolerated (digestive symptoms, metabolic acidosis). Our group developed a topical formulation of STS to treat ectopic calcifications locally, therefore limiting patient exposure to the drug and its adverse effects.

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