Open AccessNrf2 Activation Inhibits Effects of Thrombin in Human Amnion Cells and Thrombin-Induced Preterm Birth in Mice
Author(s) -
Yoshitsugu Chigusa,
A. Hari Kishore,
Haruta Mogami,
R. Ann Word
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2016-1059
Subject(s) - thrombin , amnion , medicine , endocrinology , proinflammatory cytokine , fetal membrane , chemistry , inflammation , biology , immunology , fetus , placenta , platelet , pregnancy , genetics
Nrf2 is a key transcription factor that modulates cell defense mechanisms against endogenous and exogenous stress. Previously, we reported that thrombin increased matrix metalloproteinases and prostaglandin synthesis in human amnion mesenchymal cells.
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