Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation | Zendy

Francesca Rossi | Zendy; Giulia Bellini | Zendy; Livio Luongo | Zendy; Iolanda Manzo | Zendy; Salvatore Tolone | Zendy; Chiara Tortora | Zendy; Maria Ester Bernardo | Zendy; Anna Grandone | Zendy; Antonella Conforti | Zendy; Ludovico Docimo | Zendy; Brúno Nobili | Zendy; Laura Perrone | Zendy; Franco Locatelli | Zendy; Sabatino Maione | Zendy; Emanuele Miraglia del Giudice | Zendy

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Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

Author(s) -

Francesca Rossi,

Giulia Bellini,

Livio Luongo,

Iolanda Manzo,

Salvatore Tolone,

Chiara Tortora,

Maria Ester Bernardo,

Anna Grandone,

Antonella Conforti,

Ludovico Docimo,

Brúno Nobili,

Laura Perrone,

Franco Locatelli,

Sabatino Maione,

Emanuele Miraglia del Giudice

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-4381

Subject(s) - medicine , endocrinology , adipokine , adipose tissue , perilipin , white adipose tissue , cannabinoid receptor type 2 , adipocyte , receptor , leptin , agonist , cannabinoid receptor , obesity

Obesity is associated with a low-grade inflammatory state and adipocyte (ADP) hyperplasia/hypertrophy. Obesity inhibits the "browning" of white adipose tissue. Cannabinoid receptor 2 (CB2) agonists reduce food intake and induce antiobesity effect in mice. A common missense CB2 variant, Q63R, causes CB2-reduced function.

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