Open AccessMetabolic and Transcriptional Changes in Cultured Muscle Stem Cells from Low Birth Weight Subjects
Author(s) -
Ninna S. Hansen,
Line Hjort,
Christa Broholm,
Linn Gillberg,
Maren Schrölkamp,
Heidi S. Schultz,
Brynjulf Mortensen,
Sine W. Jørgensen,
Martin Friedrichsen,
Jørgen F. P. Wojtaszewski,
Bente Klarlund Pedersen,
Allan Vaag
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2015-4214
Subject(s) - myogenesis , biology , endocrinology , medicine , glucose transporter , glut4 , myocyte , glucose uptake , stem cell , peroxisome proliferator activated receptor , microbiology and biotechnology , insulin , receptor , biochemistry
Developmental programming of human muscle stem cells could in part explain why individuals born with low birth weight (LBW) have an increased risk of developing type 2 diabetes (T2D) later in life. We hypothesized that immature muscle stem cell functions including abnormal differentiation potential and metabolic function could link LBW with the risk of developing T2D. Design/Settings/Participants: We recruited 23 young men with LBW and 16 age-matched control subjects with normal birth weight. Biopsies were obtained from vastus lateralis, and muscle stem cells were isolated and cultured into fully differentiated myotubes.
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