Acromegaly Is More Severe in Patients With AHR or AIP Gene Variants Living in Highly Polluted Areas | Zendy

Salvatore Cannavò | Zendy; M. Ragonese | Zendy; Soraya Puglisi | Zendy; Placido Romeo | Zendy; Maria Luisa Torre | Zendy; Angela Alibrandi | Zendy; Carla Scaroni | Zendy; Gianluca Occhi | Zendy; Filippo Ceccato | Zendy; Daniela Regazzo | Zendy; Ernesto De Menis | Zendy; Paola Sartorato | Zendy; Giorgio Arnaldi | Zendy; Laura Trementino | Zendy; Francesco Trimarchi | Zendy; Francesco Ferraù | Zendy

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Acromegaly Is More Severe in Patients With AHR or AIP Gene Variants Living in Highly Polluted Areas

Author(s) -

Salvatore Cannavò,

M. Ragonese,

Soraya Puglisi,

Placido Romeo,

Maria Luisa Torre,

Angela Alibrandi,

Carla Scaroni,

Gianluca Occhi,

Filippo Ceccato,

Daniela Regazzo,

Ernesto De Menis,

Paola Sartorato,

Giorgio Arnaldi,

Laura Trementino,

Francesco Trimarchi,

Francesco Ferraù

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-4191

Subject(s) - acromegaly , aryl hydrocarbon receptor , medicine , endocrinology , somatostatin , gene , physiology , biology , genetics , hormone , growth hormone , transcription factor

An increased prevalence of acromegaly was found some years ago in a highly polluted area in North-Eastern Sicily, where high concentration of nonmethane hydrocarbons, volatile organic compounds, and cadmium was found. Aryl hydrocarbon receptor (AHR) pathway has a key role in detoxification of these compounds and in tumorigenesis.

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