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Hormone Replacement Therapy Versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density
Author(s) -
Beth Cartwright,
J. Robinson,
Paul T. Seed,
Ignac Fogelman,
Janice Rymer
Publication year - 2016
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2015-4063
Subject(s) - bone mineral , medicine , hormone replacement therapy (female to male) , femoral neck , bone density , randomized controlled trial , bone remodeling , premature ovarian failure , estrogen , osteoporosis , testosterone (patch)
Women with premature ovarian failure (POF) face many years of estrogen deficiency. One of the major consequences is bone loss. The optimal form of estrogen replacement is unknown and management is not evidence based. The 2 broad options are combined hormone replacement therapy (HRT) or the combined oral contraceptive pill (COCP).

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