Effect of Teriparatide on Bone Formation in the Human Femoral Neck | Zendy

Felicia Cosman | Zendy; David W. Dempster | Zendy; Jeri W. Nieves | Zendy; Hua Zhou | Zendy; Marsha Zion | Zendy; Catherine Roimisher | Zendy; Yvonne Houle | Zendy; Robert Lindsay | Zendy; Mathias P. Bostrom | Zendy

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Effect of Teriparatide on Bone Formation in the Human Femoral Neck

Author(s) -

Felicia Cosman,

David W. Dempster,

Jeri W. Nieves,

Hua Zhou,

Marsha Zion,

Catherine Roimisher,

Yvonne Houle,

Robert Lindsay,

Mathias P. Bostrom

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3698

Subject(s) - teriparatide , femoral neck , bone remodeling , cancellous bone , urology , medicine , osteoporosis , bone mineral , bone formation , femur , chemistry , surgery

Teriparatide (TPTD) improves bone mass and microstructure resulting in reduced risk of vertebral and nonvertebral fractures. However, hip bone mineral density improvements are modest and there are no data confirming that TPTD reduces hip fracture risk. To study the effects of TPTD on the proximal femur, we performed a double-blind trial of TPTD vs placebo (PBO) in patients with osteoarthritis from whom femoral neck (FN) samples were obtained at total hip replacement (THR) surgery.

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