Open AccessParadoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization
Author(s) -
Peter Taylor,
Rebecca C. Richmond,
Neil M Davies,
Adrian Sayers,
Kirsty Stevenson,
Wolfram Woltersdorf,
Andrew M. Taylor,
Alix Groom,
Kate Northstone,
Susan M. Ring,
Onyebuchi Okosieme,
Aled Rees,
Dorothea Nitsch,
Graham R. Williams,
George Davey Smith,
John W Gregory,
Nicholas J. Timpson,
Jonathan H. Tobias,
Colin Dayan
Publication year - 2015
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2015-3505
Subject(s) - mendelian randomization , body mass index , context (archaeology) , pathological , thyroid , medicine , hormone , endocrinology , index (typography) , biology , genetics , gene , genetic variants , computer science , world wide web , genotype , paleontology
Free T3 (FT3) has been positively associated with body mass index (BMI) in cross-sectional studies in healthy individuals. This is difficult to reconcile with clinical findings in pathological thyroid dysfunction.
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