Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology | Zendy

Daniel J. Drucker | Zendy

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Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology

Author(s) -

Daniel J. Drucker

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3449

Subject(s) - biology , enteroendocrine cell , endocrine system , hormone , nutrient sensing , gastrointestinal tract , systems biology , computational biology , bioinformatics , endocrinology , microbiology and biotechnology , signal transduction , biochemistry

Classical enteroenteroendocrine cell (EEC) biology evolved historically from identification of scattered hormone-producing endocrine cells within the epithelial mucosa of the stomach, small and large intestine. Purification of functional EEC hormones from intestinal extracts, coupled with molecular cloning of cDNAs and genes expressed within EECs has greatly expanded the complexity of EEC endocrinology, with implications for understanding the contribution of EECs to disease pathophysiology.

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