Insulin Sensitivity and β-Cell Function in SGA Children Treated With GH and GnRHa: Results of a Long-Term Trial | Zendy

Manouk van der Steen | Zendy; Annemieke J. Lem | Zendy; Daniëlle C M van der Kaay | Zendy; Anita Hokken-Koelega | Zendy

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Insulin Sensitivity and β-Cell Function in SGA Children Treated With GH and GnRHa: Results of a Long-Term Trial

Author(s) -

Manouk van der Steen,

Annemieke J. Lem,

Daniëlle C M van der Kaay,

Anita Hokken-Koelega

Publication year - 2015

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3435

Subject(s) - medicine , insulin , insulin sensitivity , endocrinology , small for gestational age , randomized controlled trial , gestational age , insulin resistance , pregnancy , biology , genetics

Pubertal children born small for gestational age with a poor adult height (AH) expectation can benefit from treatment with GH 1 mg/m(2)/d (∼0.033 mg/kg/d) in combination with 2 years of GnRH analog (GnRHa) and even more so with GH 2 mg/m(2)/d. Because both GH and GnRHa can negatively influence insulin sensitivity, combining these treatments has raised concerns. The long-term GH dose effects on insulin sensitivity in children treated with combined GH/GnRHa are unknown.

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