Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells | Zendy

Weiwei Cheng | Zendy; Rengyun Liu | Zendy; Guangwu Zhu | Zendy; Hui Wang | Zendy; Mingzhao Xing | Zendy

Open Access

Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells

Author(s) -

Weiwei Cheng,

Rengyun Liu,

Guangwu Zhu,

Hui Wang,

Mingzhao Xing

Publication year - 2016

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2015-3433

Subject(s) - histone deacetylase , thyroid cancer , cancer research , thyroid , trichostatin a , medicine , histone deacetylase inhibitor , cancer , hdac11 , endocrinology , gene , histone , biology , genetics

Use of BRAF V600E inhibitors to restore thyroid iodide-handling gene expression and radioactive iodine (RAI) avidity is an attractive therapeutic strategy for RAI-refractory thyroid cancer, but recent initial clinical responses were modest. Given histone deacetylation at the sodium/iodide symporter promoter by histone deacetylase (HDAC) as a mechanism, simultaneously targeting BRAF V600E and HDAC could be a more effective strategy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research